Solutions for Pharma DMPK – DMPK workflows: HT MS for clearance determination

In the recent years there have been several MS techniques that have been developed that enables the possibility to perform MS analysis in a high throughput manner. One of the techniques is the application of the MALDI ion source in a the Rapiflex system. These techniques open the possibility to run DMPK workflows in a high throughout manner without the need of previous compounds optimization or analysis. We will present the implementation of this methodology to read and process data in a customized ADM clearance workflow with the WebQuant application.