Peptides therapeutics are becoming increasingly important on the pharmaceutical market. However, it is known that peptide drugs bioavailability and stability are lower than for small molecules. It is highly important to understand peptide drug metabolism and optimize its clearance as it influences the drug safety...

In complicated chemical reactions, like synthesis of PROTACs, the accidental generation of undesired byproducts can occur even if the conditions are well controlled (i.e. the unexpected degradation of one of the products, the interaction of solvent, catalysts and impurities with reactants, etc.). Reaction Tracking workflow...

Waters UNIFI Scientific Information System encompasses data acquisition, processing, visualization, reporting, and other tools within a networked laboratory environment. Prior MassChemSite 3.0, data providing from UNIFI specific instruments, like VION or the latest BioAccord LC-MS System. In this talk we will show how to configure...

Over the last two decades, lipids have come to be understood as far more than merely components of cellular membranes and forms of energy storage. Indeed, their pivotal role in a variety of diseases including diabetes, obesity, heart diseases, cancer, or neurodegenerative diseases, is now...

Lipid biomarker research represents one of the most widespread applications in lipidomics.  In this context, stable isotope labelling has become a staple technique in the study of lipid metabolism and dynamics, as it allows to directly measuring biosynthesis, remodeling and degradation of biomolecules.  The application...

Since the initial version of Lipostar, there have been significant strides to add features in collaboration with users to enable further data analysis in ways that other software platforms seldom provide. Here we present how the trend analysis, a new tool for global lipid profiling...